black cumin (nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects

Authors

fatemeh forouzanfar department of pharmacology, faculty of medicine, mashhad university of medical sciences, mashhad, iran

bibi sedigheh fazly bazzaz biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

hossein hosseinzadeh pharmaceutical research center, pharmacodynamy and toxicology department, school of pharmacy, mashhad university of medical sciences, mashhad, iran

abstract

nigella sativa seeds have wide therapeutic effects and have been reported to have significant effects against many ailments such as skin diseases, jaundice, gastrointestinal problems, anorexia, conjunctivitis, dyspepsia, rheumatism, diabetes, hypertension, intrinsic hemorrhage, paralysis, amenorrhea, anorexia, asthma, cough, bronchitis, headache, fever, influenza and eczema. thymoquinone (tq) is one of the most active constituent and has different beneficial properties. focus on antimicrobial effects, different extracts of n. sativa as well as tq, have a broad antimicrobial spectrum including gram-negative, gram-positive bacteria, viruses, parasites, schistosoma and fungi. the effectiveness of n. sativa seeds and tq is variable and depends on species of target microorganisms. the present review paper tries to describe all antimicrobial activities that have been carried out by various researchers.

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Journal title:
iranian journal of basic medical sciences

جلد ۱۷، شماره ۱۲، صفحات ۹۲۹-۹۳۸

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